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Journal article

Somatic point mutations in RUNX1/CBFA2/AML1 are common in high-risk myelodysplastic syndrome, but not in myelofibrosis with myeloid metaplasia.

Abstract:

OBJECTIVE: Acquired somatic point mutations in RUNX1/CBFA2/AML1 have recently been described in a subset of patients with myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML). Given the importance of core-binding factor in megakaryocytic differentiation and platelet production, as well as the central role of megakaryocytes in the pathophysiology of myelofibrosis with myeloid metaplasia (MMM), we hypothesised that RUNX1 gene mutations might be common in MMM. In addition, it is unc...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
European journal of haematology More from this journal
Volume:
74
Issue:
1
Pages:
47-53
Publication date:
2005-01-01
DOI:
EISSN:
1600-0609
ISSN:
0902-4441
Language:
English
Keywords:
Pubs id:
pubs:124961
UUID:
uuid:8d4d1e97-fc1e-497f-b49f-0f6b076718fa
Local pid:
pubs:124961
Source identifiers:
124961
Deposit date:
2012-12-19

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