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Journal article

Zika vaccines and therapeutics: landscape analysis and challenges ahead

Abstract:

Background: Various Zika virus (ZIKV) vaccine candidates are currently in development. Nevertheless, unique challenges in clinical development and regulatory pathways may hinder the licensure of high-quality, safe, and effective ZIKV vaccines.

Discussion: Implementing phase 3 efficacy trials will be difficult given the challenges of the spatio-temporal heterogeneity of ZIKV transmission, the unpredictability of ZIKV epidemics, the broad spectrum of clinical manifestations making a ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1186/s12916-018-1067-x

Authors


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Name:
European Union
Grant:
734584
More from this funder
Name:
Lee Kong Chian School of Medicine
Publisher:
BioMed Central
Journal:
BMC Medicine More from this journal
Volume:
16
Article number:
84
Publication date:
2018-06-06
Acceptance date:
2018-05-01
DOI:
EISSN:
1741-7015
Pmid:
29871628
Language:
English
Keywords:
Pubs id:
pubs:857188
UUID:
uuid:8d4606e5-e58d-4355-886c-118802cf255a
Local pid:
pubs:857188
Source identifiers:
857188
Deposit date:
2018-10-12

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