Presence of the Gpr179(nob5) allele in a C3H-derived transgenic mouse.

Balmer, J; Ji, R; Ray, TA; Selber, F; Gassmann, M; Peachey, NS; Gregg, RG; Enzmann, V

Abstract:

PURPOSE: To identify the mutation responsible for an abnormal electroretinogram (ERG) in a transgenic mouse line (tg21) overexpressing erythropoietin (Epo). The tg21 line was generated on a mixed (C3H; C57BL/6) background and lacked the b-wave component of the ERG. This no-b-wave (nob) ERG is seen in other mouse models with depolarizing bipolar cell (DBC) dysfunction and in patients with the complete form of congenital stationary night blindness (cCSNB). We determined the basis for the nob ER...

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APA Style

Balmer, J., Ji, R., Ray, T. A., Selber, F., Gassmann, M., Peachey, N. S., Gregg, R. G., & Enzmann, V. (2013). Presence of the Gpr179(nob5) allele in a C3H-derived transgenic mouse. Molecular Vision, 19, 2615–2625.

MLA Style

Balmer, J., et al. “Presence of the Gpr179(nob5) Allele in a C3H-Derived Transgenic Mouse.” Molecular Vision, vol. 19, Molecular vision, 2013, pp. 2615–25.

Chicago Style

Balmer, J, R Ji, TA Ray, F Selber, M Gassmann, NS Peachey, RG Gregg, and V Enzmann. 2013. “Presence of the Gpr179(nob5) Allele in a C3H-Derived Transgenic Mouse.” Molecular Vision 19: 2615–25.
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Authors

+ Balmer, J More by this author

Institution:

University of Oxford

Department:

Oxford, MSD, Clinical Neuroscience

Ji, R More by this author

Ray, TA More by this author

Selber, F More by this author

Gassmann, M More by this author

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Bibliographic Details

Journal:: Molecular vision
Volume:: 19
Pages:: 2615-2625
Publication date:: 2013
EISSN:: 1090-0535
ISSN:: 1090-0535
URN:: uuid:8d45795c-67c7-4a03-872d-d91860bb6e2f
Source identifiers:: 473968
Local pid:: pubs:473968

Item Description

Language:: English
Keywords:: Mice, Transgenic

Animals

Crosses, Genetic

Mice, Inbred C3H

Transgenes

Alleles

Signal Transduction

Humans

Retinal Bipolar Cells

Receptors, G-Protein-Coupled

Mutagenesis, Insertional

Electroretinography

Disease Models, Animal

Night Blindness

Mice

Male

Gene Expression

Female

Founder Effect

Erythropoietin

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