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Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam

Abstract:

To examine transmission dynamics of Mtb isolated from TB patients in Ho Chi Minh City, Vietnam we sequenced whole genomes of 1,635 isolates and compared these with 3,144 isolates from elsewhere. The data reveal an underlying burden of disease caused by endemic Mtb Lineage 1 associated with activation of long-term latent infection, and a three-fold higher burden associated with more recently introduced Beijing lineage and Lineage 4 Mtb strains. We find that Beijing lineage Mtb is frequently tr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/s41588-018-0117-9

Authors


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ORCID:
0000-0003-3949-2471
More by this author
ORCID:
0000-0001-6465-9910
Thuong, NTT More by this author
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Funding agency for:
Thwaites, G
National Health and Medical Research Council More from this funder
Agency for Science, Technology and Research More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Genetics Journal website
Volume:
50
Issue:
6
Pages:
849-856
Publication date:
2018-05-21
Acceptance date:
2018-03-22
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pubs id:
pubs:854429
URN:
uri:8d3aa22c-8c3b-49d3-bc6b-9b7b3671f0b4
UUID:
uuid:8d3aa22c-8c3b-49d3-bc6b-9b7b3671f0b4
Local pid:
pubs:854429
Language:
English
Keywords:

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