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Proteases, extracellular matrix, and cancer: a workshop of the path B study section.

Abstract:

The role of the extracellular matrix (ECM) in the tumor microenvironment is not limited to being a barrier against tumor invasion. The ECM is a reservoir of cell binding proteins and growth factors that affect tumor cell behavior. It is also substantially modified by proteases produced by tumor cells or stroma cells. As a result of the activity of these proteases, cell-cell and cell-ECM interactions are altered, new biologically active ECM molecules are generated, and the bioavailability and ...

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Publication status:
Published

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Journal:
American journal of pathology More from this journal
Volume:
164
Issue:
4
Pages:
1131-1139
Publication date:
2004-04-01
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
Language:
English
Keywords:
Pubs id:
pubs:131326
UUID:
uuid:8d33bc3d-6dfb-40dd-a83b-1e61dcae49c9
Local pid:
pubs:131326
Source identifiers:
131326
Deposit date:
2012-12-19

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