Proteases, extracellular matrix, and cancer: a workshop of the path B study section.

Journal article

The role of the extracellular matrix (ECM) in the tumor microenvironment is not limited to being a barrier against tumor invasion. The ECM is a reservoir of cell binding proteins and growth factors that affect tumor cell behavior. It is also substantially modified by proteases produced by tumor cells or stroma cells. As a result of the activity of these proteases, cell-cell and cell-ECM interactions are altered, new biologically active ECM molecules are generated, and the bioavailability and ...

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Authors: DeClerck, Y; Mercurio, A; Stack, MS; Chapman, H; Zutter, M

• Publication status: Published
• Journal: American journal of pathology
• Volume: 164
• Issue: 4
• Pages: 1131-1139
• Publication date: 2004-04-01
• DOI: 10.1016/s0002-9440(10)63200-2
• EISSN: 1525-2191
• ISSN: 0002-9440
• Language: English
• Keywords: Animals; Cell Communication; Humans; Neoplasms; Endopeptidases; Extracellular Matrix