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Discovery of 2-arylbenzoxazoles as upregulators of utrophin production for the treatment of Duchenne muscular dystrophy.

Abstract:

A series of novel 2-arylbenzoxazoles that upregulate the production of utrophin in murine H2K cells, as assessed using a luciferase reporter linked assay, have been identified. This compound class appears to hold considerable promise as a potential treatment for Duchenne muscular dystrophy. Following the delineation of structure-activity relationships in the series, a number of potent upregulators were identified, and preliminary ADME evaluation is described. These studies have resulted in th...

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Publication status:
Published

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Publisher copy:
10.1021/jm200135z

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Journal of medicinal chemistry More from this journal
Volume:
54
Issue:
9
Pages:
3241-3250
Publication date:
2011-05-01
DOI:
EISSN:
1520-4804
ISSN:
0022-2623
Language:
English
Keywords:
Pubs id:
pubs:146619
UUID:
uuid:8d327af5-e899-4d8c-8436-fad1e3e16adc
Local pid:
pubs:146619
Source identifiers:
146619
Deposit date:
2012-12-19

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