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Whole-genome methylation analysis of benign and malignant colorectal tumours

Abstract:

Changes in DNA methylation, whether hypo- or hypermethylation, have been shown to be associated with the progression of colorectal cancer. Methylation changes substantially in the progression from normal mucosa to adenoma and to carcinoma. This phenomenon has not been studied extensively and studies have been restricted to individual CpG islands, rather than taking a whole-genome approach. We aimed to study genome-wide methylation changes in colorectal cancer. We obtained 10 fresh-frozen norm...

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Publisher copy:
10.1002/path.4132

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Journal:
Journal of Pathology More from this journal
Volume:
229
Issue:
5
Pages:
697-704
Publication date:
2013-04-01
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
Pubs id:
pubs:394106
UUID:
uuid:8d325290-e24f-4f13-b082-b324a804d801
Local pid:
pubs:394106
Source identifiers:
394106
Deposit date:
2014-02-08

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