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An evolutionarily conserved coiled-coil protein implicated in polycystic kidney disease is involved in basal body duplication and flagellar biogenesis in Trypanosoma brucei.

Abstract:

Trypanosoma brucei is a flagellated protozoan with a highly polarized cellular structure. TbLRTP is a trypanosomal protein containing multiple SDS22-class leucine-rich repeats and a coiled-coil domain with high similarity to a mammalian testis-specific protein of unknown function. Homologues are present in a wide range of higher eukaryotes including zebra fish, where the gene product has been implicated in polycystic kidney disease. Western blot analysis and immunofluorescence with antibodies...

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Publication status:
Published

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Journal:
Molecular and cellular biology
Volume:
25
Issue:
9
Pages:
3774-3783
Publication date:
2005-05-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:8d1fe736-0f2e-4bb8-8f62-517cd089efdb
Source identifiers:
9376
Local pid:
pubs:9376

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