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Journal article

Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer.

Abstract:

Apart from surgical approaches, the treatment of cancer remains largely underpinned by radiotherapy and pharmacological agents that cause damage to cellular DNA, which ultimately causes cancer cell death. DNA polymerases, which are involved in the repair of cellular DNA damage, are therefore potential targets for inhibitors for improving the efficacy of cancer therapy. They can be divided, according to their main function, into two groups, namely replicative and nonreplicative enzymes. At lea...

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Publication status:
Published

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Publisher copy:
10.1089/ars.2011.4203

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Antioxidants and redox signaling More from this journal
Volume:
18
Issue:
8
Pages:
851-873
Publication date:
2013-03-01
DOI:
EISSN:
1557-7716
ISSN:
1523-0864
Language:
English
Keywords:
Pubs id:
pubs:342343
UUID:
uuid:8d1f63bf-1af9-4500-bae5-96ee8448feed
Local pid:
pubs:342343
Source identifiers:
342343
Deposit date:
2013-11-17

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