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Prazosin, an α(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease

Abstract:

Noradrenergic deficits have been described in the hippocampus and the frontal cortex of Alzheimer's disease brains, which are secondary to locus coeruleus degeneration. Locus coeruleus is the brain stem nucleus responsible for synthesis of noradrenaline and from where all noradrenergic neurons project. In addition, it has been suggested that noradrenaline might play a role in modulating inflammatory responses in Alzheimer's disease. In this study we aimed to investigate the effect of various ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Department:
Oxford, MSD, NDM, Target Discovery Institute
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Neurobiology of Aging Journal website
Volume:
34
Issue:
4
Pages:
1105-1115
Publication date:
2012-10-11
Acceptance date:
2012-09-07
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
Pubs id:
pubs:614443
URN:
uri:8d1e4ce9-fd34-4fc2-92fa-2ad758a092b2
UUID:
uuid:8d1e4ce9-fd34-4fc2-92fa-2ad758a092b2
Local pid:
pubs:614443
Paper number:
4

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