Journal article
Prazosin, an α(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease
- Abstract:
-
Noradrenergic deficits have been described in the hippocampus and the frontal cortex of Alzheimer's disease brains, which are secondary to locus coeruleus degeneration. Locus coeruleus is the brain stem nucleus responsible for synthesis of noradrenaline and from where all noradrenergic neurons project. In addition, it has been suggested that noradrenaline might play a role in modulating inflammatory responses in Alzheimer's disease. In this study we aimed to investigate the effect of various ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1016/j.neurobiolaging.2012.09.010
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Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Neurobiology of Aging Journal website
- Volume:
- 34
- Issue:
- 4
- Pages:
- 1105-1115
- Publication date:
- 2012-10-11
- Acceptance date:
- 2012-09-07
- DOI:
- EISSN:
-
1558-1497
- ISSN:
-
0197-4580
- Pmid:
-
23063647
- Source identifiers:
-
614443
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:614443
- UUID:
-
uuid:8d1e4ce9-fd34-4fc2-92fa-2ad758a092b2
- Local pid:
- pubs:614443
- Deposit date:
- 2016-09-13
Terms of use
- Copyright holder:
- © 2013 Elsevier Inc All rights reserved
- Copyright date:
- 2012
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