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Prediction of Chromatin Accessibility in Gene-Regulatory Regions from Transcriptomics Data

Abstract:

The epigenetics landscape of cells plays a key role in the establishment of cell-type specific gene expression programs characteristic of different cellular phenotypes. Different experimental procedures have been developed to obtain insights into the accessible chromatin landscape including DNase-seq, FAIRE-seq and ATAC-seq. However, current downstream computational tools fail to reliably determine regulatory region accessibility from the analysis of these experimental data. In particular, cu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's versions

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Publisher copy:
10.1038/s41598-017-04929-6

Authors


Angarica, VE More by this author
Andrade-Navarro, MA More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Del Sol, A More by this author
Publisher:
Springer Nature Publisher's website
Journal:
Scientific reports Journal website
Volume:
7
Issue:
1
Pages:
4660
Publication date:
2017-07-05
Acceptance date:
2017-05-22
DOI:
ISSN:
2045-2322
Pubs id:
pubs:709736
URN:
uri:8d08c587-8ba5-4998-8dea-88ec7d2e91f6
UUID:
uuid:8d08c587-8ba5-4998-8dea-88ec7d2e91f6
Local pid:
pubs:709736
Language:
English
Keywords:

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