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A molecular marker of artemisinin-resistant Plasmodium falciparum malaria.

Abstract:

Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens malaria control and elimination activities worldwide. To monitor the spread of artemisinin resistance, a molecular marker is urgently needed. Here, using whole-genome sequencing of an artemisinin-resistant parasite line from Africa and clinical parasite isolates from Cambodia, we associate mutations in the PF3D7_1343700 kelch propeller domain ('K13-propeller') with artemisinin resistance in vitro and in vi...

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Publication status:
Published

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Publisher copy:
10.1038/nature12876

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Journal:
Nature
Volume:
505
Issue:
7481
Pages:
50-55
Publication date:
2014-01-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Source identifiers:
444249

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