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Shared paramyxoviral glycoprotein architecture is adapted for diverse attachment strategies.

Abstract:

Members within the paramyxovirus subfamily Paramyxovirinae constitute a large number of highly virulent human and animal pathogens. The glycoproteins present on these viruses are responsible for mediating host cell attachment and fusion and are key targets for the design of antiviral entry inhibitors. In the present review, we discuss recent structural studies which have led to a better understanding of the various mechanisms by which different paramyxoviruses use their attachment glycoprotei...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1042/bst0381349

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Publisher:
Portland Press for the Biochemical Society Publisher's website
Journal:
Biochemical Society transactions Journal website
Volume:
38
Issue:
5
Pages:
1349-1355
Publication date:
2010-10-01
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
Source identifiers:
73347
Language:
English
Keywords:
Pubs id:
pubs:73347
UUID:
uuid:8cf8b633-c161-4b26-8571-2db75fca9724
Local pid:
pubs:73347
Deposit date:
2012-12-19

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