Pedunculopontine stimulation from primate to patient.

Journal article

Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here we summarise our non-human primate investigations of relevance to our surgical targeting of the PPN and relate the primate research to initial clinical experience of PPN DBS.

Authors: Pereira, E; Nandi, D; Jenkinson, N; Stein, J; Green, A

• Publication status: Published
• Journal: Journal of neural transmission (Vienna, Austria : 1996)
• Volume: 118
• Issue: 10
• Pages: 1453-1460
• Publication date: 2011-10-01
• DOI: 10.1007/s00702-011-0631-8
• EISSN: 1435-1463
• ISSN: 0300-9564
• Language: English
• Keywords: Convulsants; Biophysics; GABA-A Receptor Agonists; Macaca; Bicuculline; Animals; Pedunculopontine Tegmental Nucleus; Parkinson Disease; Male; Disease Models, Animal; Deep Brain Stimulation; Humans; Muscimol; History, 20th Century