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A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways

Abstract:

Otitis media (OM), inflammation of the middle ear (ME), is a common cause of conductive hearing impairment. Despite the importance of the disease, the aetiology of chronic and recurrent forms of middle ear inflammatory disease remains poorly understood. Studies of the human population suggest that there is a significant genetic component predisposing to the development of chronic OM, although the underlying genes are largely unknown. Using N-ethyl-N-nitrosourea mutagenesis we identified a rec...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1006969

Authors


Crompton, M More by this author
Purnell, T More by this author
Hardisty-Hughes, RE More by this author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
13
Issue:
8
Pages:
Article: e1006969
Publication date:
2017-08-14
Acceptance date:
2017-08-11
DOI:
EISSN:
1553-7404
ISSN:
1553-739
Pubs id:
pubs:723891
URN:
uri:8cf4a746-59a3-410a-8c5e-6670c23bb951
UUID:
uuid:8cf4a746-59a3-410a-8c5e-6670c23bb951
Local pid:
pubs:723891

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