The Jumonji-C (JmjC) subfamily of 2-oxoglutarate (2OG)-dependent oxygenases are of biomedical interest because of their roles in the regulation of gene expression and protein biosynthesis. Human JmjC 2OG oxygenases catalyze oxidative modifications to give either chemically stable alcohol products, or in the case of N(ɛ)-methyl lysine demethylation, relatively unstable hemiaminals that fragment to give formaldehyde and the demethylated product. Recent work has yielded conflicting reports as to...Expand abstract
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- Markolovic et al.
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Copyright © 2016 The Authors. Published by Elsevier Ltd. This is an
open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Structure–function relationships of human JmjC oxygenases — demethylases versus hydroxylases
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