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Journal article

Structure–function relationships of human JmjC oxygenases — demethylases versus hydroxylases

Abstract:

The Jumonji-C (JmjC) subfamily of 2-oxoglutarate (2OG)-dependent oxygenases are of biomedical interest because of their roles in the regulation of gene expression and protein biosynthesis. Human JmjC 2OG oxygenases catalyze oxidative modifications to give either chemically stable alcohol products, or in the case of N(ɛ)-methyl lysine demethylation, relatively unstable hemiaminals that fragment to give formaldehyde and the demethylated product. Recent work has yielded conflicting reports as to...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
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Name:
Ludwig Institute for Cancer Research
More from this funder
Name:
Engineering and Physical Sciences Research Council
Publisher:
Elsevier
Journal:
Current opinion in structural biology More from this journal
Volume:
41
Pages:
62-72
Publication date:
2016-06-14
Acceptance date:
2016-06-14
DOI:
EISSN:
1879-033X
ISSN:
0959-440X
Language:
English
Pubs id:
pubs:628635
UUID:
uuid:8cf46d5d-9d37-4b2b-8e67-536f8ea5cd38
Local pid:
pubs:628635
Source identifiers:
628635
Deposit date:
2016-06-23

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