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Are whole-exome and whole-genome sequencing approaches cost-effective? A systematic review of the literature

Abstract:

Purpose: We conducted a systematic literature review to summarize the current health economic evidence for whole-exome sequencing (WES) and whole-genome sequencing (WGS).

Methods: Relevant studies were identified in the EMBASE, MEDLINE, Cochrane Library, EconLit and University of York Centre for Reviews and Dissemination databases from January 2005 to July 2016. Publications were included in the review if they were economic evaluations, cost studies, or outcome studies.

Results...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/gim.2017.247

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health; Population Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health; Population Health
Oxford college:
Oriel College
Role:
Author
ORCID:
0000-0003-2528-0638
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
ORCID:
0000-0003-3602-5704
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health; Population Health
Role:
Author
UK Health Innovation Challenge Fund More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Genetics in Medicine Journal website
Volume:
20
Pages:
1122–1130
Publication date:
2018-02-15
Acceptance date:
2017-11-27
DOI:
EISSN:
1530-0366
ISSN:
1098-3600
Pmid:
29446766
Source identifiers:
825633
Language:
English
Keywords:
Pubs id:
pubs:825633
UUID:
uuid:8cf329bc-73f9-41c0-b27b-3d944f8f9096
Local pid:
pubs:825633
Deposit date:
2018-02-28

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