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The contribution of major histocompatibility complex contacts to the affinity and kinetics of T cell receptor binding

Abstract:

The interaction between the T cell antigen receptor (TCR) and antigenic peptide in complex with major histocompatibility complex (MHC) molecules is a crucial step in T cell activation. The relative contributions of TCR:peptide and TCR:MHC contacts to the overall binding energy remain unclear. This has important implications for our understanding of T cell development and function. In this study we used site directed mutagenesis to estimate the contribution of HLA-A2 side-chains to the b...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep35326

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Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Role:
Author
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Funding agency for:
Dushek, O
Grant:
Sir Henry Dale Fellowship (098363
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Funding agency for:
Dushek, O
Grant:
Sir Henry Dale Fellowship (098363
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Funding agency for:
van der Merwe, P
Grant:
Senior Investigator Award (101799/Z/13/Z
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Grant:
C19634/A6659
C19634/A12336
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Publication date:
2016-10-13
Acceptance date:
2016-09-28
DOI:
ISSN:
2045-2322
Source identifiers:
647414
Pubs id:
pubs:647414
UUID:
uuid:8cf144ca-5766-4bf1-b2c0-f59a3fbce3b3
Local pid:
pubs:647414
Deposit date:
2016-09-30

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