Journal article
The contribution of major histocompatibility complex contacts to the affinity and kinetics of T cell receptor binding
- Abstract:
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The interaction between the T cell antigen receptor (TCR) and antigenic peptide in complex with major histocompatibility complex (MHC) molecules is a crucial step in T cell activation. The relative contributions of TCR:peptide and TCR:MHC contacts to the overall binding energy remain unclear. This has important implications for our understanding of T cell development and function. In this study we used site directed mutagenesis to estimate the contribution of HLA-A2 side-chains to the b...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.9MB)
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- Publisher copy:
- 10.1038/srep35326
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Authors
Funding
+ Wellcome Trust
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Funding agency for:
Dushek, O
Grant:
Sir Henry Dale Fellowship (098363
+ Royal Society
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Funding agency for:
Dushek, O
Grant:
Sir Henry Dale Fellowship (098363
+ Wellcome Trust
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Funding agency for:
van der Merwe, P
Grant:
Senior Investigator Award (101799/Z/13/Z
EPA Research Trust
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Scientific Reports Journal website
- Publication date:
- 2016-10-13
- Acceptance date:
- 2016-09-28
- DOI:
- ISSN:
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2045-2322
- Source identifiers:
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647414
Item Description
- Pubs id:
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pubs:647414
- UUID:
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uuid:8cf144ca-5766-4bf1-b2c0-f59a3fbce3b3
- Local pid:
- pubs:647414
- Deposit date:
- 2016-09-30
Terms of use
- Copyright holder:
- Zhang et al
- Copyright date:
- 2016
- Notes:
- This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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