- Abstract:
-
It has been suggested that receptor-ligand complexes segregate or co-localise within immune synapses according to their size, and this is important for receptor signaling. Here, we set out to test the importance of receptor-ligand complex dimensions for immune surveillance of target cells by human Natural Killer (NK) cells. NK cell activation is regulated by integrating signals from activating receptors, such as NKG2D, and inhibitory receptors, such as KIR2DL1. Elongating the NKG2D ligand MIC...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.5mb)
-
- Publisher copy:
- 10.1371/journal.pone.0015374
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 5
- Issue:
- 11
- Pages:
- e15374
- Publication date:
- 2010
- DOI:
- EISSN:
-
1932-6203
- ISSN:
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1932-6203
- URN:
-
uuid:8cec9f15-3067-4848-b78f-c49c5f9f10cb
- Source identifiers:
-
107082
- Local pid:
- pubs:107082
- Language:
- English
- Keywords:
- Copyright holder:
- Kohler et al.
- Copyright date:
- 2010
- Notes:
- Copyright 2010 Kohler et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human natural killer cells.
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