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Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human natural killer cells.

Abstract:

It has been suggested that receptor-ligand complexes segregate or co-localise within immune synapses according to their size, and this is important for receptor signaling. Here, we set out to test the importance of receptor-ligand complex dimensions for immune surveillance of target cells by human Natural Killer (NK) cells. NK cell activation is regulated by integrating signals from activating receptors, such as NKG2D, and inhibitory receptors, such as KIR2DL1. Elongating the NKG2D ligand MIC...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0015374

Authors


Köhler, K More by this author
Brzostek, J More by this author
Mehrabi, M More by this author
Eissmann, P More by this author
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Biotechnology and Biological Sciences Research Council More from this funder
Medical Research Council More from this funder
Wolfson Royal Society More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
5
Issue:
11
Pages:
e15374
Publication date:
2010
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:8cec9f15-3067-4848-b78f-c49c5f9f10cb
Source identifiers:
107082
Local pid:
pubs:107082

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