Journal article
Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human natural killer cells.
- Abstract:
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It has been suggested that receptor-ligand complexes segregate or co-localise within immune synapses according to their size, and this is important for receptor signaling. Here, we set out to test the importance of receptor-ligand complex dimensions for immune surveillance of target cells by human Natural Killer (NK) cells. NK cell activation is regulated by integrating signals from activating receptors, such as NKG2D, and inhibitory receptors, such as KIR2DL1. Elongating the NKG2D ligand MIC...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.5MB)
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- Publisher copy:
- 10.1371/journal.pone.0015374
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Authors
Funding
Biotechnology and Biological Sciences Research Council
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Medical Research Council
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Wolfson Royal Society
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 5
- Issue:
- 11
- Pages:
- e15374
- Publication date:
- 2010-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
- Source identifiers:
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107082
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:8cec9f15-3067-4848-b78f-c49c5f9f10cb
- Local pid:
- pubs:107082
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Kohler et al
- Copyright date:
- 2010
- Notes:
- Copyright 2010 Kohler et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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