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Journal article

Phase 3 efficacy analysis of a typhoid conjugate vaccine trial in Nepal

Abstract:

BACKGROUND

Salmonella Typhi is a major cause of fever in children in low- and middle-income countries. A typhoid conjugate vaccine (TCV) that was recently prequalified by the World Health Organization was shown to be efficacious in a human challenge model, but data from efficacy trials in areas where typhoid is endemic are lacking.

METHODS

In this phase 3, randomized, controlled trial in Lalitpur, Nepal, in which both the participants...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1056/NEJMoa1905047

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Oxford college:
All Souls College
Role:
Author
ORCID:
0000-0001-6324-6559
More by this author
Institution:
University of Oxford
Division:
ContEd
Role:
Author
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Publisher:
Massachusetts Medical Society Publisher's website
Journal:
New England Journal of Medicine Journal website
Volume:
381
Pages:
2209-2218
Publication date:
2019-12-05
Acceptance date:
2019-09-23
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
Source identifiers:
1061403
Language:
English
Keywords:
Pubs id:
pubs:1061403
UUID:
uuid:8ce8419d-d155-4ff3-a610-0a79eebcdf50
Local pid:
pubs:1061403
Deposit date:
2019-10-10

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