Phase 3 efficacy analysis of a typhoid conjugate vaccine trial in Nepal
Salmonella Typhi is a major cause of fever in children in low- and middle-income countries. A typhoid conjugate vaccine (TCV) that was recently prequalified by the World Health Organization was shown to be efficacious in a human challenge model, but data from efficacy trials in areas where typhoid is endemic are lacking.
In this phase 3, randomized, controlled trial in Lalitpur, Nepal, in which both the participants...Expand abstract
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- Peer reviewed
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- Massachusetts Medical Society
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- © 2019 Massachusetts Medical Society. All rights reserved.
- This is the publisher's version of the article. The final version is available online from the Massachusetts Medical Society at: https://doi.org/10.1056/NEJMoa1905047
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