Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome.

Journal article

Mutations in LKB1 lead to Peutz-Jeghers syndrome (PJS). However, only a subset of PJS patients harbours LKB1 mutations. We performed a mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in 28 LKB1-negative PJS patients. No disease-causing mutations were detected in the studied genes in PJS patients from different European populations.

Authors: Alhopuro, P; Katajisto, P; Lehtonen, R; Ylisaukko-Oja, S; Näätsaari, L

• Publication status: Published
• Journal: British journal of cancer
• Volume: 92
• Issue: 6
• Pages: 1126-1129
• Publication date: 2005-03-01
• DOI: 10.1038/sj.bjc.6602454
• EISSN: 1532-1827
• ISSN: 0007-0920
• Language: English
• Keywords: Adaptor Proteins, Vesicular Transport; Humans; Nuclear Proteins; DNA Helicases; Mutation; Polymorphism, Genetic; Transcription Factors; Introns; Peutz-Jeghers Syndrome; Adaptor Proteins, Signal Transducing