- Abstract:
-
Glucagon-like peptide 1 (GLP-1) is a potent inhibitor of food intake. GLP-1 receptor mRNA is densely expressed in hypothalamic arcuate nucleus (ARC) and precisely overlaps the area occupied by proopiomelanocortin (POMC) neurons. Activation of POMC neurons suppresses appetite, and lack of POMC-derived peptides or inhibition of POMC neuronal firing causes obesity. Here, we identify living POMC cells in mouse ARC brain slices by targeted expression of green fluorescent protein. Using whole-cell ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1523/jneurosci.1025-07.2007
-
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- Journal:
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- Volume:
- 27
- Issue:
- 27
- Pages:
- 7125-7129
- Publication date:
- 2007-07-05
- DOI:
- EISSN:
-
1529-2401
- ISSN:
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0270-6474
- URN:
-
uuid:8cc0c628-685e-42a2-ba0e-e09830b36cbc
- Source identifiers:
-
113373
- Local pid:
- pubs:113373
- Copyright date:
- 2007
Journal article
Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons.
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