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Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons.

Abstract:

Glucagon-like peptide 1 (GLP-1) is a potent inhibitor of food intake. GLP-1 receptor mRNA is densely expressed in hypothalamic arcuate nucleus (ARC) and precisely overlaps the area occupied by proopiomelanocortin (POMC) neurons. Activation of POMC neurons suppresses appetite, and lack of POMC-derived peptides or inhibition of POMC neuronal firing causes obesity. Here, we identify living POMC cells in mouse ARC brain slices by targeted expression of green fluorescent protein. Using whole-cell ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
27
Issue:
27
Pages:
7125-7129
Publication date:
2007-07-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:8cc0c628-685e-42a2-ba0e-e09830b36cbc
Source identifiers:
113373
Local pid:
pubs:113373

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