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Journal article

Myocardial substrate metabolism in obesity

Abstract:

Obesity is linked to a wide variety of cardiac changes, from subclinical diastolic dysfunction to end-stage systolic heart failure. Obesity causes changes in cardiac metabolism, which make ATP production and utilization less efficient, producing functional consequences that are linked to the increased rate of heart failure in this population. As a result of the increases in circulating fatty acids and insulin resistance that accompanies excess fat storage, several of the proteins and genes th...

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Publication status:
Accepted
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/ijo.2012.170

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Strategic
Publisher:
Nature Publishing Group Publisher's website
Journal:
International Journal of Obesity Journal website
Volume:
37
Issue:
7
Pages:
972-979
Publication date:
2012-10-16
Acceptance date:
2012-09-02
DOI:
EISSN:
1476-5497
ISSN:
0307-0565
URN:
uuid:8cbdbe53-c81c-4347-8ea4-35c58bee8793
Source identifiers:
415668
Local pid:
pubs:415668
Keywords:

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