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CD11c(high )dendritic cells are essential for activation of CD4+ T cells and generation of specific antibodies following mucosal immunization.

Abstract:

To generate vaccines that protect mucosal surfaces, a better understanding of the cells required in vivo for activation of the adaptive immune response following mucosal immunization is required. CD11c(high) conventional dendritic cells (cDCs) have been shown to be necessary for activation of naive CD8(+) T cells in vivo, but the role of cDCs in CD4(+) T cell activation is still unclear, especially at mucosal surfaces. The activation of naive Ag-specific CD4(+) T cells and the generation of A...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.0803992

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Journal:
Journal of Immunology
Volume:
183
Issue:
8
Pages:
5032-5041
Publication date:
2009-10-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
4901

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