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Extensive genetic diversity in the HLA class II region of Africans, with a focally predominant allele, DRB1*1304.

Abstract:

Molecular HLA class II typing of greater than 1700 individuals from The Gambia in West Africa and Malawi in South-Central Africa revealed a striking diversity of HLA DRB-DQB haplotypes as defined by restriction fragment length polymorphism (RFLP); this diversity is twice as extensive as that found in northern Europeans. Despite this diversity, sequence and PCR/oligonucleotide analysis showed that the recently described variant DRB1*1304 is the commonest DRB1 allele in The Gambia. The sequence...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.89.6.2277

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
89
Issue:
6
Pages:
2277-2281
Publication date:
1992-03-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
32469

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