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Clarithromycin and endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps: study protocol for the MACRO randomised controlled trial

Abstract:

Background Chronic rhinosinusitis (CRS) is a common source of ill health; 11% of UK adults reported CRS symptoms in a worldwide population study. Guidelines are conflicting regarding whether antibiotics should be included in primary medical management, reflecting the lack of evidence in systematic reviews. Insufficient evidence to inform the role of surgery contributes to a fivefold variation in UK intervention rates. The objective of this trial is to establish the compara...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13063-019-3314-7

Authors


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Role:
Author
ORCID:
0000-0002-1125-3236
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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Oxford college:
St Hugh's College
Role:
Author
ORCID:
0000-0002-4156-6989
Publisher:
BioMed Central Publisher's website
Journal:
Trials Journal website
Volume:
20
Issue:
1
Article number:
246
Publication date:
2019-04-29
Acceptance date:
2019-03-21
DOI:
EISSN:
1745-6215
Language:
English
Keywords:
Pubs id:
pubs:995014
UUID:
uuid:8caf3877-b896-41d1-a94a-c5451a35e07f
Local pid:
pubs:995014
Source identifiers:
995014
Deposit date:
2019-04-30

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