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Bad to the bone: The role of the insulin-like growth factor axis in osseous metastasis

Abstract:

Bone metastases are a frequent complication of cancer that are associated with considerable morbidity. Current treatments may temporarily palliate the symptoms of bone metastases but often fail to delay their progression. Bones provide a permissive environment because they are characterized by dynamic turnover, secreting factors required for bone maintenance but also stimulating the establishment and growth of metastases. Insulin-like growth factors (IGF) are the most abundant growth factors ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1158/1078-0432.ccr-18-2697

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
ORCID:
0000-0001-8659-0192
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Role:
Author
ORCID:
0000-0001-9917-514X
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Name:
Rosetrees Trust
Grant:
M330-F1
Publisher:
American Association for Cancer Research
Journal:
Clinical Cancer Research More from this journal
Volume:
25
Issue:
12
Pages:
3479-3485
Publication date:
2019-02-11
Acceptance date:
2019-02-06
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
Pmid:
30745299
Language:
English
Keywords:
Pubs id:
pubs:974392
UUID:
uuid:8cacf22d-b212-467e-86b5-1298421a4896
Local pid:
pubs:974392
Source identifiers:
974392
Deposit date:
2019-06-21

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