Journal article icon

Journal article

Sample size requirements for separating out the effects of combination treatments: randomised controlled trials of combination therapy vs. standard treatment compared to factorial designs for patients with tuberculous meningitis.

Abstract:

BACKGROUND: In certain diseases clinical experts may judge that the intervention with the best prospects is the addition of two treatments to the standard of care. This can either be tested with a simple randomized trial of combination versus standard treatment or with a 2 x 2 factorial design. METHODS: We compared the two approaches using the design of a new trial in tuberculous meningitis as an example. In that trial the combination of 2 drugs added to standard treatment is assumed to reduc...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1186/1745-6215-12-26

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Journal:
Trials More from this journal
Volume:
12
Issue:
1
Pages:
26
Publication date:
2011-01-01
DOI:
EISSN:
1745-6215
ISSN:
1745-6215
Language:
English
Keywords:
Pubs id:
pubs:115776
UUID:
uuid:8ca08b1d-2926-4f3f-8648-91f36dc1065f
Local pid:
pubs:115776
Source identifiers:
115776
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP