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Exploring the effects of symmetric arginine methylation readers on E2F1- dependent transcriptional output in vitro

Abstract:

E2F1 plays contrasting biological roles in both cellular proliferation and apoptosis. Recent studies have demonstrated that residue-specific arginine dimethylation marks deposited by PRMT1 and PRMT5 mediate the apoptotic and proliferative activity of E2F1 respectively. Two readers of the proliferative symmetric arginine dimethylation mark deposited by PRMT5 on E2F1 have since been identified: TSN and TDRD1. In this study, qRT-PCR analysis was used to validate the deregulation of candidate ...

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Department:
University of Oxford
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Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford

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