Neurogenomic evidence for a shared mechanism of the antidepressant effects of exercise and chronic fluoxetine in mice.

Journal article

Several different interventions improve depressed mood, including medication and environmental factors such as regular physical exercise. The molecular pathways underlying these effects are still not fully understood. In this study, we sought to identify shared mechanisms underlying antidepressant interventions. We studied three groups of mice: mice treated with a widely used antidepressant drug--fluoxetine, mice engaged in voluntary exercise, and mice living in an enriched environment. The h...

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Authors: Huang, G; Ben-David, E; Tort Piella, A; Edwards, A; Flint, J

• Publication status: Published
• Journal: PloS one
• Volume: 7
• Issue: 4
• Pages: e35901
• Publication date: 2012-01-01
• DOI: 10.1371/journal.pone.0035901
• EISSN: 1932-6203
• ISSN: 1932-6203
• Language: English
• Keywords: Humans; Metabolic Networks and Pathways; Animals; Neurogenesis; Depression; Male; Antidepressive Agents; Physical Conditioning, Animal; Mice; Neurons; Fluoxetine; Gene Expression; Mice, Inbred BALB C; Exercise Therapy; Hippocampus