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Expression of HIV in lymph node cells of LAS patients. Immunohistology, in situ hybridization, and identification of target cells.

Abstract:

Monoclonal antibodies (MAb) anti-HIV core and envelope proteins and in situ hybridization, using cDNA HIV probe, were employed to determine which lymph node cells in LAS patients express viral antigens and viral nucleic acids. The results have been correlated with the histologic phases of LAS and with the germinal center lysis detected using DRC-1 MAb directed against follicular dendritic reticulum cells (FDRC). Viral antigens occasionally were detected on high endothelial cells of paracortic...

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences
Role:
Author
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Journal:
The American journal of pathology
Volume:
133
Issue:
3
Pages:
498-506
Publication date:
1988-12-05
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:8c960885-045a-4478-8b14-2cd33ac3a579
Source identifiers:
486749
Local pid:
pubs:486749

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