Journal article
Adenovirus VA RNAI blocks ASC oligomerization and inhibits NLRP3 inflammasome activation
- Abstract:
-
Virus infected immune cells can rapidly respond to the invader by activating the inflammasome and as a consequence release proinflammatory cytokines and eventually die by pyroptosis. In human adenovirus-5 (Ad5) infected THP-1 cells, inhibition of NLRP3 inflammasome activation was demonstrated by a decreased secretion of HMGB1 and matured forms of caspase-1and IL-1ß. An Ad5 mutant virus defective in expression of the non-coding VA RNAI failed to inhibit the NLRP3 inflammasome and in addition d...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Frontiers Media Publisher's website
- Journal:
- Frontiers in Immunology Journal website
- Volume:
- 10
- Publication date:
- 2019-11-28
- Acceptance date:
- 2019-11-14
- DOI:
- EISSN:
-
1664-3224
Item Description
- Keywords:
- Pubs id:
-
1111560
- Local pid:
- pubs:1111560
- Deposit date:
- 2020-06-11
Terms of use
- Copyright holder:
- Darweesh, Kamel, Gavrilin, Akusjärvi and Svensson
- Copyright date:
- 2020
- Rights statement:
- Copyright © 2019 Darweesh, Kamel, Gavrilin, Akusjärvi and Svensson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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