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Adenovirus VA RNAI blocks ASC oligomerization and inhibits NLRP3 inflammasome activation

Abstract:

Virus infected immune cells can rapidly respond to the invader by activating the inflammasome and as a consequence release proinflammatory cytokines and eventually die by pyroptosis. In human adenovirus-5 (Ad5) infected THP-1 cells, inhibition of NLRP3 inflammasome activation was demonstrated by a decreased secretion of HMGB1 and matured forms of caspase-1and IL-1ß. An Ad5 mutant virus defective in expression of the non-coding VA RNAI failed to inhibit the NLRP3 inflammasome and in addition d...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2019.02791
Publisher:
Frontiers Media
Journal:
Frontiers in Immunology More from this journal
Volume:
10
Publication date:
2019-11-28
Acceptance date:
2019-11-14
DOI:
EISSN:
1664-3224
Keywords:
Pubs id:
1111560
Local pid:
pubs:1111560
Deposit date:
2020-06-11

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