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Journal article

Reprint: Good laboratory practice: preventing introduction of bias at the bench.

Abstract:
As a research community, we have failed to demonstrate that drugs that show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Accumulating evidence suggests that this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments, which create a systematic bias resulting in the overstatement of neuroprotective efficacy. Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke.
Publication status:
Published

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Journal:
International journal of stroke : official journal of the International Stroke Society More from this journal
Volume:
4
Issue:
1
Pages:
3-5
Publication date:
2009-02-01
DOI:
EISSN:
1747-4949
ISSN:
1747-4930
Language:
English
Keywords:
Pubs id:
pubs:84590
UUID:
uuid:8c8b1827-c973-46c3-bf5c-c2a67590d79d
Local pid:
pubs:84590
Source identifiers:
84590
Deposit date:
2012-12-19

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