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Phenotypic and molecular characterization of a serum-free miniature erythroid differentiation system suitable for high-throughput screening and single-cell assays

Abstract:

In vitro erythroid differentiation systems are used to study the mechanisms underlying normal and abnormal erythropoiesis and to test the effects of various extracellular factors on erythropoiesis. The use of serum or conditioned medium in liquid cultures, and seeding cultures with heterogeneous peripheral blood mononuclear cells confound the reproducibility of these systems. Newer erythroid differentiation culture systems have overcome some of these limitations by using a fully defined, seru...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.exphem.2018.01.001

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Strategic
Oxford college:
Green Templeton College
Role:
Author
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More from this funder
Grant:
MC_UU_12025/ unit programme MC_UU_12009/4 to DRH
More from this funder
Grant:
Oxford Biomedical Research Centre to DRH
Publisher:
Elsevier Publisher's website
Journal:
Experimental Hematology Journal website
Volume:
60
Pages:
10-20
Publication date:
2018-01-09
Acceptance date:
2018-01-02
DOI:
ISSN:
0301-472X
Pubs id:
pubs:815388
URN:
uri:8c84d55d-f822-4ebf-bda3-3327b62bdc19
UUID:
uuid:8c84d55d-f822-4ebf-bda3-3327b62bdc19
Local pid:
pubs:815388

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