Evaluation of the effects of human leukocyte IFN-alpha on the immune response to the HBV vaccine in healthy unvaccinated individuals.

Journal article

HBV vaccine needs 3 injections over 6 months to induce immunity. Thus, the use of adjuvants capable of inducing earlier immune protection would be highly desirable. Most adjuvants may act by inducing cytokines, and among them, type I interferons (IFNs), deserve a special attention in view of the potent immunomostimulatory activity observed in mouse models and on dendritic cell functions. The aim of the present trial was to evaluate the effects of IFN-alpha administered as an adjuvant of HBV v...

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Authors: Rizza, P; Capone, I; Urbani, F; Montefiore, E; Rapicetta, M

• Publication status: Published
• Journal: Vaccine
• Volume: 26
• Issue: 8
• Pages: 1038-1049
• Publication date: 2008-02-01
• DOI: 10.1016/j.vaccine.2007.12.044
• EISSN: 1873-2518
• ISSN: 0264-410X
• Language: English
• Keywords: Female; Humans; Hepatitis B Vaccines; Adolescent; Enzyme-Linked Immunosorbent Assay; Leukocytes, Mononuclear; CD4-Positive T-Lymphocytes; Lymphocyte Subsets; Adjuvants, Immunologic; Hepatitis B Antibodies; Middle Aged; Adult; Male; Interferon-gamma; Aged; CD8-Positive T-Lymphocytes; Interferon-alpha; Immunoglobulin G; Flow Cytometry