Hidden heritability due to heterogeneity across seven populations.

Journal article

Meta-analyses of genome-wide association studies (GWAS), which dominate genetic discovery are based on data from diverse historical time periods and populations. Genetic scores derived from GWAS explain only a fraction of the heritability estimates obtained from whole-genome studies on single populations, known as the 'hidden heritability' puzzle. Using seven sampling populations (N=35,062), we test whether hidden heritability is attributed to heterogeneity across sampling populations and tim...

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Authors: Tropf, FC; Lee, SH; Verweij, RM; Stulp, G; van der Most, PJ

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Publishing Group Publisher's website
• Journal: Nature Human Behaviour Journal website
• Volume: 1
• Issue: 10
• Pages: 757-765
• Publication date: 2017-09-01
• Acceptance date: 2017-08-04
• DOI: 10.1038/s41562-017-0195-1
• EISSN: 2397-3374
• ISSN: 2397-3374
• Pmid: 29051922
• Language: English
• Keywords: gene-environment interaction; educational attainment; hidden heritability; age at first birth; human reproduction; missing heritability