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A novel mutation in a patient with a deficiency of the eighth component of complement associated with recurrent meningococcal meningitis.

Abstract:

INTRODUCTION: Complement component C8 is one of the five terminal complement components required for the formation of the membrane attack complex. Complete absence of C8 results in increased susceptibility to gram-negative bacteria such as Neisseria species. MATERIALS AND METHODS: Two functionally distinct C8 deficiency states have been described: C8 alpha-gamma deficiency has been predominantly reported amongst Afro-Caribbeans, Hispanics, and Japanese and C8beta mainly in Caucasians. RESULT...

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Publication status:
Published

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Publisher copy:
10.1007/s10875-009-9295-7

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Journal:
Journal of clinical immunology
Volume:
29
Issue:
5
Pages:
691-695
Publication date:
2009-09-01
DOI:
EISSN:
1573-2592
ISSN:
0271-9142
Source identifiers:
66501

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