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Schizophrenia-related dysbindin-1 gene is required for innate immune response and homeostasis in the developing subventricular zone

Abstract:

Schizophrenia is a neurodevelopmental disorder likely caused by environmental and genetic risk factors but functional interactions between the risk factors are unclear. We tested the hypothesis that dysbindin-1 (Dtnbp1) gene mutation combined with postnatal exposure to viral mimetic polyI:C results in schizophrenia-related behavioural changes in adulthood, and mediates polyI:C-induced inflammation in the subventricular zone (SVZ). Adult Sandy (Sdy, Dtnbp1 mutant) mice given early postnatal po...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41537-018-0057-5

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
St Anne's College
Role:
Author
Canadian Institutes of Health Research More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
NPJ Schizophrenia Journal website
Volume:
4
Issue:
1
Pages:
15
Publication date:
2018-07-23
Acceptance date:
2018-06-11
DOI:
EISSN:
2334-265X
ISSN:
2334-265X
Pmid:
30038210
Source identifiers:
891455
Language:
English
Keywords:
Pubs id:
pubs:891455
UUID:
uuid:8c6c47dc-a6c9-430a-89a1-c7321a812de6
Local pid:
pubs:891455
Deposit date:
2018-08-07

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