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Journal article

Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo

Abstract:

Steroid 5β-reductase (AKR1D1) is highly expressed in human liver where it inactivates endogenous glucocorticoids and catalyses an important step in bile acid synthesis. Endogenous and synthetic glucocorticoids are potent regulators of metabolic phenotype and play a crucial role in hepatic glucose metabolism. However, the potential of synthetic glucocorticoids to be metabolised by AKR1D1 as well as to regulate its expression and activity has not been investigated. The impact of glucocorticoids...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1530/joe-19-0473

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Oxford college:
Keble College
Role:
Author
ORCID:
0000-0002-8789-8436
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Name:
Medical Research Council
Grant:
MR/P011462/1
Publisher:
Bioscientifica
Journal:
The Journal of Endocrinology More from this journal
Volume:
245
Issue:
2
Pages:
207–218
Publication date:
2020-02-27
Acceptance date:
2020-02-27
DOI:
EISSN:
1479-6805
ISSN:
0022-0795
Pmid:
32106090
Language:
English
Keywords:
Pubs id:
1090152
Local pid:
pubs:1090152
Deposit date:
2020-03-13

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