Treatment with histamine H2 antagonists in acute upper gastrointestinal hemorrhage. Implications of randomized trials.
Histamine H2 antagonists are widely used in treating patients with hematemesis and melena, despite the lack of reliable evidence of benefit from any of the randomized trials, considered separately. Examination of the data from all 27 available randomized trials, in which over 2500 patients were entered, suggests that treatment may reduce the rates of rebleeding, surgery, and death by about 10, 20, and 30 per cent, respectively, although these results were only marginally significant for surge...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date: