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Journal article

Four-stranded mini microtubules formed by Prosthecobacter BtubAB show dynamic instability

Abstract:

Microtubules, the dynamic, yet stiff hollow tubes built from αβ-tubulin protein heterodimers, are thought to be present only in eukaryotic cells. Here, we report a 3.6-Å helical reconstruction electron cryomicroscopy structure of four-stranded mini microtubules formed by bacterial tubulin-like Prosthecobacter dejongeii BtubAB proteins. Despite their much smaller diameter, mini microtubules share many key structural features with eukaryotic microtubules, such as an M-loop, alternating subunits...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1073/pnas.1705062114

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
ORCID:
0000-0002-0168-0277
Kureisaite-Ciziene, D More by this author
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Boehringer Ingelheim Fonds More from this funder
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Grant:
Leopoldina Fellowship LPDS 2013-06
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
114
Issue:
29
Pages:
E5950-E5958
Publication date:
2017-07-18
Acceptance date:
2017-06-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:710735
URN:
uri:8c67b9bb-7d64-4c0b-99e1-e5cd36407657
UUID:
uuid:8c67b9bb-7d64-4c0b-99e1-e5cd36407657
Local pid:
pubs:710735
Paper number:
29

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