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Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant protein-1 but not IL-1beta or IL-6.

Abstract:

Activation of p38 mitogen-activated protein kinase (MAPK) is known to be important in cytokine production and cell survival in inflammation. This study examined the effect of inhibiting p38 MAPK after onset of renal injury in an experimental model of crescentic glomerulonephritis. Furthermore, this study investigated whether p38 MAPK inhibition would cause widespread suppression of the cytokine network in vivo or uncontrolled apoptosis. In the in vivo studies, daily treatment with a p38 MAPKa...

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Publication status:
Published

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Publisher copy:
10.1681/asn.2006010050

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Journal:
Journal of the American Society of Nephrology : JASN More from this journal
Volume:
18
Issue:
4
Pages:
1167-1179
Publication date:
2007-04-01
DOI:
EISSN:
1533-3450
ISSN:
1046-6673
Language:
English
Keywords:
Pubs id:
pubs:217274
UUID:
uuid:8c60d571-6f63-47a1-a244-3bcbefc48f01
Local pid:
pubs:217274
Source identifiers:
217274
Deposit date:
2012-12-19

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