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A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis

Abstract:

PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRDM9-bound loci do not become recombination hotspots. To explore factors that affect binding and subsequent recombination outcomes, we mapped human PRDM9 binding sites in a transfected human cell line and measured PRDM9-induced histone modifications. These data reveal varied DNA-binding modalities of PRDM9. We also find that human PRDM9 frequently binds promoters, despite their low recombination ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Role:
Author
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Name:
Wellcome Trust
Grant:
086817/Z/08/Z
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Name:
Cancer Research UK
Grant:
C52690/A19270
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Name:
Medical Research Council
Grant:
MR/L009609/1
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Name:
Foreign and Commonwealth Office
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Name:
Howard Hughes Medical Institute
Publisher:
eLife Sciences
Journal:
eLife More from this journal
Volume:
6
Pages:
e28383
Publication date:
2017-10-26
Acceptance date:
2017-10-24
DOI:
ISSN:
2050-084X
Pubs id:
pubs:811843
UUID:
uuid:8c5764e8-1155-4773-97c6-17027e0c4d7d
Local pid:
pubs:811843
Source identifiers:
811843
Deposit date:
2018-07-20

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