- Abstract:
-
The influenza virus RNA-dependent RNA polymerase (RdRP) cleaves the 5′ end of nascent capped host RNAs and uses the capped RNA fragment to prime viral transcription in a mechanism called ‘cap snatching’. Cap snatching requires an intimate association between influenza RdRP and cellular RNA polymerase II (Pol II), which is the source of nascent capped host RNAs targeted by influenza virus. Recent structural studies have revealed how influenza RdRP binds to Pol II and how this binding promotes ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 3.7mb)
-
- Publisher copy:
- 10.1016/j.tim.2018.12.013
-
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- Publisher:
- Cell Press Publisher's website
- Journal:
- Trends in Microbiology Journal website
- Volume:
- 27
- Issue:
- 5
- Pages:
- 398-407
- Publication date:
- 2019-01-11
- Acceptance date:
- 2018-12-20
- DOI:
- ISSN:
-
0966-842X
- Pubs id:
-
pubs:953574
- URN:
-
uri:8c53a037-df6f-4e16-b28e-62b38466dafb
- UUID:
-
uuid:8c53a037-df6f-4e16-b28e-62b38466dafb
- Local pid:
- pubs:953574
- Keywords:
- Copyright holder:
- Walker and Fodor
- Copyright date:
- 2019
- Notes:
- Copyright © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Journal article
Interplay between influenza virus and the host RNA polymerase II transcriptional machinery
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