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Interplay between influenza virus and the host RNA polymerase II transcriptional machinery

Abstract:

The influenza virus RNA-dependent RNA polymerase (RdRP) cleaves the 5′ end of nascent capped host RNAs and uses the capped RNA fragment to prime viral transcription in a mechanism called ‘cap snatching’. Cap snatching requires an intimate association between influenza RdRP and cellular RNA polymerase II (Pol II), which is the source of nascent capped host RNAs targeted by influenza virus. Recent structural studies have revealed how influenza RdRP binds to Pol II and how this binding promotes ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.tim.2018.12.013

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Oxford college:
Exeter College
Publisher:
Cell Press Publisher's website
Journal:
Trends in Microbiology Journal website
Volume:
27
Issue:
5
Pages:
398-407
Publication date:
2019-01-11
Acceptance date:
2018-12-20
DOI:
ISSN:
0966-842X
Pubs id:
pubs:953574
URN:
uri:8c53a037-df6f-4e16-b28e-62b38466dafb
UUID:
uuid:8c53a037-df6f-4e16-b28e-62b38466dafb
Local pid:
pubs:953574

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