Heterogeneity of B cells reacting with T-cell factors. Evidence for matching T-cell and B-cell subsets.

Journal article

Spleen T cells have been stimulated with Concanavalin A (Con A) under conditions which lead to the production of non-specific factor (NSF), a substance which replaces T cells for B-cell responses to certain antigens. We have examined the ability of multiple aliquots of B cells to react to the NSF derived from single T cells, and have found great heterogeneity of response. We postulate that there exist subsets of T cells which vary in either the quantity or the quality of the non-specific fact...

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Authors: Lefkovits, I; Waldmann, H

• Publication status: Published
• Journal: Immunology
• Volume: 32
• Issue: 6
• Pages: 915-922
• Publication date: 1977-06-01
• EISSN: 1365-2567
• ISSN: 0019-2805
• Language: English
• Keywords: Lymphokines; T-Lymphocytes; Mathematics; Cells, Cultured; Mice; Lymphocyte Activation; Animals; Mice, Inbred BALB C; B-Lymphocytes