Genetic analyses in a sample of individuals with high or low BMD shows association with multiple Wnt pathway genes.
UNLABELLED: Using a moderate-sized cohort selected with extreme BMD (n = 344; absolute value BMD, 1.5-4.0), significant association of several members of the Wnt signaling pathway with bone densitometry measures was shown. This confirms that extreme truncate selection is a powerful design for quantitative trait association studies of bone phenotypes. INTRODUCTION: Although the high heritability of BMD variation has long been established, few genes have been conclusively shown to affect the v...Expand abstract
- Publication status:
- Publisher copy:
- Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
- Publication date:
- Source identifiers:
- Copyright date: