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Genetic analyses in a sample of individuals with high or low BMD shows association with multiple Wnt pathway genes.

Abstract:

UNLABELLED: Using a moderate-sized cohort selected with extreme BMD (n = 344; absolute value BMD, 1.5-4.0), significant association of several members of the Wnt signaling pathway with bone densitometry measures was shown. This confirms that extreme truncate selection is a powerful design for quantitative trait association studies of bone phenotypes. INTRODUCTION: Although the high heritability of BMD variation has long been established, few genes have been conclusively shown to affect the v...

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Publication status:
Published

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Publisher copy:
10.1359/jbmr.071113

Authors


Shephard, N More by this author
Dowling, A More by this author
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Journal:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume:
23
Issue:
4
Pages:
499-506
Publication date:
2008-04-05
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
URN:
uuid:8c5194cb-2bf3-4ed3-92bc-00e2a854e9ae
Source identifiers:
23571
Local pid:
pubs:23571

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