- Abstract:
-
UNLABELLED: Using a moderate-sized cohort selected with extreme BMD (n = 344; absolute value BMD, 1.5-4.0), significant association of several members of the Wnt signaling pathway with bone densitometry measures was shown. This confirms that extreme truncate selection is a powerful design for quantitative trait association studies of bone phenotypes. INTRODUCTION: Although the high heritability of BMD variation has long been established, few genes have been conclusively shown to affect the v...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1359/jbmr.071113
-
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- Journal:
- Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
- Volume:
- 23
- Issue:
- 4
- Pages:
- 499-506
- Publication date:
- 2008-04-05
- DOI:
- EISSN:
-
1523-4681
- ISSN:
-
0884-0431
- URN:
-
uuid:8c5194cb-2bf3-4ed3-92bc-00e2a854e9ae
- Source identifiers:
-
23571
- Local pid:
- pubs:23571
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Genetic analyses in a sample of individuals with high or low BMD shows association with multiple Wnt pathway genes.
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