Thesis icon

Thesis

Targeting protein-protein interactions for cancer therapy

Abstract:

Protein-protein interactions (PPIs) are key drug targets and recent breakthroughs in this area are providing insight into the types of molecules needed to selectively and potently inhibit a target traditionally seen as untractable. The rules that have been used to design classic substratecompetitive drugs (for example Lipinski's rule of five) may not apply in this new field in the same way. Here I present work performed in three systems that are well-validated drug targets for oncogenesis:...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Institution:
University of Oxford
Oxford college:
Magdalen College
Department:
Medical Sciences Division - Biochemistry

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:8c40e01c-769a-4e86-a76b-4bd3bf341177
Local pid:
ora:12430
Language:
English
Keywords:
Subjects:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP