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A mutation in the 3' region of the human immunodeficiency virus type 1 reverse transcriptase (Y318F) associated with nonnucleoside reverse transcriptase inhibitor resistance.

Abstract:

The Y318F substitution in the 3' region of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) has been linked to nonnucleoside RT inhibitor (NNRTI) resistance in vitro. A systematic search of a large phenotypic-genotypic database (Virco) linked the Y318F substitution with a >10-fold decrease in NNRTI susceptibility in >85% of clinically derived isolates. There was a significant association between Y318F and use of delavirdine (P = 10(-11)) and nevirapine (P = 10(-6))...

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Publication status:
Published

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Journal:
Journal of virology More from this journal
Volume:
76
Issue:
13
Pages:
6836-6840
Publication date:
2002-07-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Language:
English
Keywords:
Pubs id:
pubs:72609
UUID:
uuid:8c3cac3d-3254-4c8e-abfb-19f97af8c715
Local pid:
pubs:72609
Source identifiers:
72609
Deposit date:
2012-12-19

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