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Improved conditions for the generation of beta oscillations in the subthalamic nucleus--globus pallidus network.

Abstract:

A key pathology in the development of Parkinson's disease is the occurrence of persistent beta oscillations, which are correlated with difficulty in movement initiation. We investigated the network model composed of the subthalamic nucleus (STN) and globus pallidus (GP) developed by A. Nevado Holgado et al. [(2010) Journal of Neuroscience, 30, 12340-12352], who identified the conditions under which this circuit could generate beta oscillations. Our work extended their analysis by deriving imp...

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
European journal of neuroscience More from this journal
Volume:
36
Issue:
2
Pages:
2229-2239
Publication date:
2012-07-01
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
Language:
English
Keywords:
Pubs id:
pubs:420755
UUID:
uuid:8c3ba215-b162-4b82-baa7-86206b8c0cb9
Local pid:
pubs:420755
Source identifiers:
420755
Deposit date:
2013-11-16

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