Improved conditions for the generation of beta oscillations in the subthalamic nucleus--globus pallidus network.

Journal article

A key pathology in the development of Parkinson's disease is the occurrence of persistent beta oscillations, which are correlated with difficulty in movement initiation. We investigated the network model composed of the subthalamic nucleus (STN) and globus pallidus (GP) developed by A. Nevado Holgado et al. [(2010) Journal of Neuroscience, 30, 12340-12352], who identified the conditions under which this circuit could generate beta oscillations. Our work extended their analysis by deriving imp...

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Authors: Pavlides, A; Hogan, S; Bogacz, R

• Publication status: Published
• Journal: European journal of neuroscience
• Volume: 36
• Issue: 2
• Pages: 2229-2239
• Publication date: 2012-07-01
• DOI: 10.1111/j.1460-9568.2012.08105.x
• EISSN: 1460-9568
• ISSN: 0953-816X
• Language: English
• Keywords: Nerve Net; Synaptic Transmission; Humans; GABAergic Neurons; Beta Rhythm; Parkinson Disease; Subthalamic Nucleus; Models, Neurological; Globus Pallidus