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Thesis

Genetic variation contributing to autoimmune disease

Abstract:

Genetic variants influencing the IL-2 signaling pathway, including IL2RA , which encodes CD25, the alpha chain of the IL-2 receptor, are enriched in autoimmune diseases. Regulatory T cells (Tregs) are vital to the maintenance of a balanced immune system. They require IL-2 for their survival and by expressing high levels of CD25 are exquisitely sensitive to this cytokine. My thesis has focused on (1) accurate quantification and understanding of the heterogeneous nature of Tregs and (2) ana...

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Division:
MSD
Department:
NDM
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:8c3b59b4-cc95-4378-bd99-8395beeb8d47
Language:
English
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